This study investigates the effects of hypoxia and iron on ascorbic acid-mediated cytotoxicity in prostate cancer cell lines. Ascorbic acid, known for its pro-oxidant properties at high concentrations, can induce cytotoxic effects in cancer cells by generating reactive oxygen species (ROS). However, factors like hypoxia and iron availability may influence its efficacy. Hypoxia, a common feature of the tumor microenvironment, can alter cellular metabolism and oxidative stress responses, potentially affecting ascorbic acid-induced cytotoxicity. Additionally, iron plays a crucial role in redox reactions and may enhance or mitigate the oxidative damage caused by ascorbic acid. Understanding these interactions can provide insights into optimizing ascorbic acid-based therapies for prostate cancer treatment.
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